منابع مشابه
The action of chlorphenesin carbamate on the frog spinal cord.
Studies were carried out to elucidate the mechanism of action of chlorphenesin carbamate (CPC) and to compare the effect of the drug with that of mephenesin on the isolated bullfrog spinal cord. Ventral and dorsal root potentials were recorded by means of the sucrose-gap method. CPC caused marked hyperpolarizations and depressed spontaneous activities in both of the primary afferent terminals (...
متن کاملPresynaptic action of barbiturates in the frog spinal cord.
The action of pentobarbital on primary afferents of the isolated frog spinal cord was analyzed with sucrose gap and intracellular recordings techniques. Pentobarbital in concentrations generally considered to be in the anesthetic range greatly prolonged presynaptic inhibition and also depolarized primary afferents. The depolarization was accompanied by an increase in excitability and resulted f...
متن کاملGABA and bicuculline actions on mouse spinal cord and cortical neurons in cell culture.
The neutral amino acid gamma-aminobutyric acid (GABA) produced membrane hyperpolarization and increased membrane chloride ion conductance of spinal cord (SC) and cortical (CTX) neurons in cell culture. GABA dose-response curves were obtained for SC neurons by pressure applying known concentrations of GABA from micropipettes with large tips (miniperfusion pipettes). GABA response threshold was a...
متن کاملBicuculline-sensitive primary afferent depolarization remains after greatly restricting synaptic transmission in the mammalian spinal cord.
Primary afferent neurotransmission is the fundamental first step in the central processing of sensory stimuli. A major mechanism producing afferent presynaptic inhibition is via a channel-mediated depolarization of their intraspinal terminals which can be recorded extracellularly as a dorsal root potential (DRP). Based on measures of DRP latency it has been inferred that this primary afferent d...
متن کاملPrimitive roles for inhibitory interneurons in developing frog spinal cord.
Understanding the neuronal networks in the mammal spinal cord is hampered by the diversity of neurons and their connections. The simpler networks in developing lower vertebrates may offer insights into basic organization. To investigate the function of spinal inhibitory interneurons in Xenopus tadpoles, paired whole-cell recordings were used. We show directly that one class of interneuron, with...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1974
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1974.tb09684.x